SequelSEC

Spero Therapeutics, Inc. SPRO

Pharmaceutical Preparations · CIK 0001701108 · Fiscal year ends 1231

Revenue
$66.80M
Fiscal year ended 2025-12-31
Operating income
$6.31M
Fiscal year ended 2025-12-31
Free cash flow
Unavailable
Fiscal year ended 2025-12-31

Valuation, from the filing

Public float$160.30MMarket value of stock held by non-affiliates, as stated on the cover page for 2025-06-30
Float per share$2.77Float divided by shares outstanding in the same filing. A floor under the share price on that date, not the price itself.
Float / net income18.7×A lower bound on the multiple, because affiliate holdings are excluded.
Float / revenue2.4×A lower bound on the multiple, because affiliate holdings are excluded.
Float / equity2.7×A lower bound on the multiple, because affiliate holdings are excluded.

Every figure here is drawn from the 10-K cover page and the statements behind it, so each one traces to a filing. Public float counts only stock held by non-affiliates, which makes these floors rather than estimates: a high multiple is conclusive, a low one may mean cheap or may mean closely held. The float was measured on 2025-06-30, not today, and each multiple below it uses the figures for the fiscal year ending 2025-12-31 — the year that filing covered.

How this compares in its industry

Percentile among the Pharmaceutical Preparations filers on this site, highest value first. A high percentile means a large figure, which is good for a margin and not for leverage — the ranking says where the company sits, not whether that is where it should be.

MeasureReportedPercentile
Net margin12.8%86th
Operating margin9.5%84th
SBC / revenue6.5%25th
Current ratio7.59x72th
Revenue YoY growth39.2%72th
Effective tax rate3.0%31th
R&D / revenue57.6%37th

Spero Therapeutics, Inc. (SPRO) reported revenue of $66.80M and net income of $8.57M for the fiscal year ended 2025-12-31. This page shows 10 annual periods of income statement, balance sheet and cash flow figures normalized from Spero Therapeutics, Inc.’s SEC filings, each linked to the filing it came from. It is classified by the SEC under Pharmaceutical Preparations.

Income

Spero Therapeutics, Inc. income by fiscal year, in US dollars, normalized from SEC filings.
Metric2025-12-312024-12-312023-12-312022-12-312021-12-312020-12-312019-12-312018-12-312017-12-312016-12-31
Revenue$66.80M$47.98M$103.78M$53.51M$18.26M$9.33M$18.15M$3.97M$1.98M$335.00K
Cost of revenueUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailable
Gross profitUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailable
Operating income$6.31M-$73.36M$21.48M-$42.20M-$87.97M-$79.11M-$63.22M-$42.81M-$41.73M-$33.22M
Net income$8.57M-$68.57M$22.81MUnavailable-$89.80M-$78.30M-$60.90M-$41.70M-$38.74M-$25.49M
Research & development$38.47M$96.76M$51.44M$47.59M$64.53M$67.00M$65.78M$33.88M$32.87M$26.33M
Weighted-average diluted sharesshares 59.04Mshares 54.04Mshares 52.99Mshares 37.59Mshares 30.90MUnavailableUnavailableUnavailableUnavailableUnavailable
Pretax income$8.83M-$68.57M$25.40M-$46.42M-$89.76M-$78.28M-$60.92M-$41.66M-$39.89M-$32.64M
Income tax expense$261.00K$0$2.60M$0$0$0$0$0$0$0
Diluted EPS$0.15$-1.27$0.43$-1.23$-2.91UnavailableUnavailableUnavailableUnavailableUnavailable
Selling, general & administrativeUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailable
General & administrative$21.18M$23.70M$25.55M$36.48M$41.70M$21.44M$15.59M$12.89M$10.84M$7.22M
Selling & marketingUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailable

Balance

Spero Therapeutics, Inc. balance by fiscal year, in US dollars, normalized from SEC filings.
Metric2025-12-312024-12-312023-12-312022-12-312021-12-312020-12-312019-12-312018-12-312017-12-312016-12-31
Cash & equivalents$40.26M$52.89M$76.33M$109.11M$112.58M$85.21M$29.73M$34.08M$87.29M$10.32M
Total assets$68.92M$110.54M$182.39M$124.80M$171.07M$153.45M$106.10M$129.01M$93.48M$13.77M
Current assets$67.29M$107.28M$131.21M$113.57M$157.87M$139.14M$95.41M$124.22M$92.06M$11.87M
Total liabilities$9.90M$64.42M$75.50M$48.87M$82.78M$21.41M$31.53M$13.15M$8.52M$7.41M
Current liabilities$8.87M$49.07M$37.15M$21.65M$18.67M$14.34M$26.66M$12.32M$8.16M$6.92M
Total equity incl. NCI$59.02M$46.12M$106.89M$75.93M$88.29M$132.04M$74.57M$115.86M$84.96M-$49.25M
Temporary (mezzanine) equityUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailable$47.68M
InventoryUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailable
Accounts receivableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailable
GoodwillUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailable
Long-term debtUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailable
Accounts payable$693.00K$7.31M$1.38M$617.00K$1.10M$1.16M$4.15M$3.60M$3.47M$1.14M

Cash flow

Spero Therapeutics, Inc. cash flow by fiscal year, in US dollars, normalized from SEC filings.
Metric2025-12-312024-12-312023-12-312022-12-312021-12-312020-12-312019-12-312018-12-312017-12-312016-12-31
Operating cash flow-$12.62M-$23.44M-$33.00M-$7.73M-$64.35M-$85.87M-$50.02M-$39.62M-$39.11M-$28.96M
Capital expendituresUnavailableUnavailableUnavailableUnavailableUnavailable$157.00K$314.00K$2.44M$27.00K$830.00K
Investing cash flowUnavailableUnavailable$0$33.81M$7.67M$10.47M$29.53M-$83.16M-$27.00K-$830.00K
Financing cash flowUnavailable$0$221.00K-$29.55M$84.05M$130.88M$16.14M$69.52M$116.11M$34.41M
Net change in cash-$12.62M-$23.44M-$32.77M-$3.48M$27.38M$55.48M-$4.35M-$53.26M$76.97M$4.62M
Stock-based compensation$4.32M$7.79M$7.93M$9.12M$9.43M$4.89M$3.78M$2.75M$1.43M$180.00K
Common dividends paidUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailable
Common share repurchasesUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailable
Depreciation & amortization$0$2.00K$367.00K$869.00K$646.00K$761.00K$750.00K$409.00K$363.00K$279.00K

Derived

Spero Therapeutics, Inc. derived by fiscal year, in US dollars, normalized from SEC filings.
Metric2025-12-312024-12-312023-12-312022-12-312021-12-312020-12-312019-12-312018-12-312017-12-312016-12-31
Free cash flowUnavailableUnavailableUnavailableUnavailableUnavailableUnavailable-$50.33M-$42.06M-$39.14M-$29.79M
Gross marginUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailable
Operating margin9.5%-152.9%20.7%-78.9%-481.9%-847.9%-348.4%-1079.3%-2108.6%-9916.7%
FCF marginUnavailableUnavailableUnavailableUnavailableUnavailableUnavailable-277.4%-1060.5%-1977.7%-8892.2%
SBC / revenue6.5%16.2%7.6%17.0%51.7%52.4%20.8%69.3%72.1%53.7%
Current ratio7.59x2.19x3.53x5.25x8.46x9.70x3.58x10.08x11.29x1.72x
Revenue YoY growth39.2%-53.8%94.0%193.1%95.7%-48.6%357.6%100.4%490.7%Unavailable
Net margin12.8%-142.9%22.0%UnavailableUnavailable-839.2%-335.6%-1051.4%-1957.7%-7609.3%
R&D / revenue57.6%201.7%49.6%88.9%353.5%718.1%362.5%854.4%1660.9%7860.6%
CapEx / revenueUnavailableUnavailableUnavailableUnavailableUnavailableUnavailable1.7%61.4%1.4%247.8%
Long-term debt / equityUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailable
Effective tax rate3.0%Unavailable10.2%UnavailableUnavailableUnavailableUnavailableUnavailableUnavailableUnavailable

Amounts are abbreviated; the exact reported value is carried in each cell. — means unavailable, not zero. Open SPRO in the interactive workspace to inspect any figure back to its filing.

Source filings

10-Q · Filed 2026-08-12View SEC filing
10-Q · Filed 2026-05-13View SEC filing
10-K · Filed 2026-03-26View SEC filing
10-Q · Filed 2025-11-13View SEC filing
10-Q · Filed 2025-08-12View SEC filing
10-Q · Filed 2025-05-13View SEC filing

Companies in the same industry

Reconciliation checks needing review

1 period on this page do not reconcile under this site’s normalization. Read that as a limitation here before an observation about the company: the figures are the filer’s own, the filings linked above are authoritative, and a difference usually means the concepts this site selected do not match how this filer presents its statements. Nothing is adjusted to make a check pass.

balance equationreview2016-12-31

Difference 7924000 exceeds tolerance 1000000. Presentation or filing-vintage differences need review.