SequelSEC

Septerna, Inc. SEPN

Pharmaceutical Preparations · CIK 0001984086 · Fiscal year ends 1231

Revenue
$45.95M
Fiscal year ended 2025-12-31
Operating income
-$68.30M
Fiscal year ended 2025-12-31
Free cash flow
$109.67M
Fiscal year ended 2025-12-31

Valuation, from the filing

Public float$363.30MMarket value of stock held by non-affiliates, as stated on the cover page for 2025-06-30
Float per share$8.09Float divided by shares outstanding in the same filing. A floor under the share price on that date, not the price itself.
Float / revenue7.9×A lower bound on the multiple, because affiliate holdings are excluded.
Float / equity1.0×A lower bound on the multiple, because affiliate holdings are excluded.

Every figure here is drawn from the 10-K cover page and the statements behind it, so each one traces to a filing. Public float counts only stock held by non-affiliates, which makes these floors rather than estimates: a high multiple is conclusive, a low one may mean cheap or may mean closely held. The float was measured on 2025-06-30, not today, and each multiple below it uses the figures for the fiscal year ending 2025-12-31 — the year that filing covered.

How this compares in its industry

Percentile among the Pharmaceutical Preparations filers on this site, highest value first. A high percentile means a large figure, which is good for a margin and not for leverage — the ranking says where the company sits, not whether that is where it should be.

MeasureReportedPercentile
FCF margin238.7%100th
Revenue YoY growth4174.5%99th
CapEx / revenue1.1%41th
Current ratio4.73x58th
Operating margin-148.6%54th
R&D / revenue212.4%53th
Net margin-106.4%53th
SBC / revenue18.4%47th

Septerna, Inc. (SEPN) reported revenue of $45.95M and net income of -$48.88M for the fiscal year ended 2025-12-31. This page shows 3 annual periods of income statement, balance sheet and cash flow figures normalized from Septerna, Inc.’s SEC filings, each linked to the filing it came from. It is classified by the SEC under Pharmaceutical Preparations.

Income

Septerna, Inc. income by fiscal year, in US dollars, normalized from SEC filings.
Metric2025-12-312024-12-312023-12-31
Revenue$45.95M$1.08M$151.00K
Cost of revenueUnavailableUnavailableUnavailable
Gross profitUnavailableUnavailableUnavailable
Operating income-$68.30M-$80.82M$2.08M
Net income-$48.88M-$71.80M$4.18M
Research & development$97.58M$65.34M$35.98M
Weighted-average diluted sharesshares 44.26Mshares 9.89Mshares 2.18M
Pretax income-$48.87M-$72.30M-$48.87M
Income tax expense$12.00K-$498.00K$691.00K
Diluted EPS$-1.10$-7.26$0.29
Selling, general & administrativeUnavailableUnavailableUnavailable
General & administrative$29.16M$16.56M$9.72M
Selling & marketingUnavailableUnavailableUnavailable

Balance

Septerna, Inc. balance by fiscal year, in US dollars, normalized from SEC filings.
Metric2025-12-312024-12-312023-12-31
Cash & equivalents$120.72M$238.20M$88.48M
Total assets$596.19M$456.55M$130.87M
Current assets$410.96M$356.82M$112.68M
Total liabilities$214.26M$36.51M$20.03M
Current liabilities$86.93M$12.85M$6.91M
Total equity incl. NCI$381.93M$420.05M-$38.37M
Temporary (mezzanine) equityUnavailableUnavailable$149.22M
InventoryUnavailableUnavailableUnavailable
Accounts receivable$10.36M$171.00K$151.00K
GoodwillUnavailableUnavailableUnavailable
Long-term debtUnavailableUnavailableUnavailable
Accounts payable$10.28M$3.20M$2.64M

Cash flow

Septerna, Inc. cash flow by fiscal year, in US dollars, normalized from SEC filings.
Metric2025-12-312024-12-312023-12-31
Operating cash flow$110.19M-$67.47M-$38.72M
Capital expenditures$518.00K$2.10M$2.88M
Investing cash flow-$229.35M-$160.60M$22.12M
Financing cash flow$1.69M$377.78M$74.52M
Net change in cash-$117.47M$149.71M$57.92M
Stock-based compensation$8.48M$3.15M$1.62M
Common dividends paidUnavailableUnavailableUnavailable
Common share repurchasesUnavailableUnavailableUnavailable
Depreciation & amortization$1.60M$1.40M$800.00K

Derived

Septerna, Inc. derived by fiscal year, in US dollars, normalized from SEC filings.
Metric2025-12-312024-12-312023-12-31
Free cash flow$109.67M-$69.57M-$41.60M
Gross marginUnavailableUnavailableUnavailable
Operating margin-148.6%-7518.4%1374.2%
FCF margin238.7%-6471.9%-27550.3%
SBC / revenue18.4%293.2%1072.8%
Current ratio4.73x27.77x16.30x
Revenue YoY growth4174.5%611.9%Unavailable
Net margin-106.4%-6678.9%2768.2%
R&D / revenue212.4%6077.9%23827.2%
CapEx / revenue1.1%195.6%1906.0%
Long-term debt / equityUnavailableUnavailableUnavailable
Effective tax rateUnavailableUnavailableUnavailable

Amounts are abbreviated; the exact reported value is carried in each cell. — means unavailable, not zero. Open SEPN in the interactive workspace to inspect any figure back to its filing.

Source filings

10-Q · Filed 2026-08-10View SEC filing
10-Q · Filed 2026-05-11View SEC filing
10-K · Filed 2026-03-09View SEC filing
10-Q · Filed 2025-11-10View SEC filing
10-Q · Filed 2025-08-11View SEC filing
10-Q · Filed 2025-05-15View SEC filing

Companies in the same industry

Every accounting identity this site checks — the balance sheet, the gross profit bridge and the cash flow statement — reconciles in every period shown.